Category: Publications

Published November 2023 in iScience, in collaboration with Medical University Innsbruck Non-coding RNAs (ncRNAs) are pivotal in gene regulation during development and disease. MicroRNAs have been extensively studied in neurogenesis. However, limited knowledge exists about the developmental signatures of other ncRNA species in sensory neuron differentiation, and human dorsal root ganglia (DRG) ncRNA expression remains […]

Accepted October 2023 in Development, in collaboration with University of Edinburgh. The emergence of definitive human haematopoietic stem cells (HSCs) during Carnegie Stages (CS) 14-17 in the aorta-gonad-mesonephros (AGM) region is a tightly regulated process. Previously, we conducted spatial transcriptomic analysis of the human AGM region at the end of this period (CS16/17) and identified […]

Accepted October 2023 in Gene, in collaboration with Heidelberg University. S-adenosylmethionine (SAM) represents a potent inhibitor of cancer cell proliferation, migration, and invasion in vitro. The underlying mechanisms remain elusive. Here, we examined, if treatment with SAM may cause alterations in the methylation of the histone marks H3K4me3 and H3K27me3, which are both known to […]

Published March 2023 in EMBO Molecular Medicine, in collaboration with Freie Universität Berlin and University of Cambridge. Neurodegenerative diseases are increasingly prevalent in the aging population, yet no disease-modifying treatments are currently available. Increasing the expression of the cold-shock protein RBM3 through therapeutic hypothermia is remarkably neuroprotective. However, systemic cooling poses a health risk, strongly […]

Published March 2023 in Science Advances, in collaboration with Freie Universität Berlin and the Lührmann group from MPI for Multidisciplinary Sciences Göttingen. Alternative precursor messenger RNA splicing is instrumental in expanding the proteome of higher eukaryotes, and changes in 3′ splice site (3’ss) usage contribute to human disease. We demonstrate by small interfering RNA–mediated knockdowns, […]

Published February 2023 in Biochemical and Biophysical Research Communications, in collaboration with Freie Universität Berlin. RNA-Seq has become the standard approach to quantify and compare gene expression and alternative splicing in different conditions. In many cases the limiting factor is not the sequencing itself but the bioinformatic analysis. A variety of software tools exist that […]

Published December 2022 in Life Science Alliance, in collaboration with Freie Universität Berlin. Species-specific regulation and functionality of alternative splicing remained unknown to date. Calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) is expressed in several splice variants and plays a key role in learning and memory. In the present study, we investigated and characterised several primate-specific CAMK2B splice isoforms. […]

Published July 2022 in Nucleic Acids Research, in collaboration with Freie Universität Berlin. Antiviral innate immunity represents the first defense against invading viruses and is key to control viral infections, including SARS-CoV-2. Body temperature is an omnipresent variable but was neglected when addressing host defense mechanisms and susceptibility to SARS-CoV-2 infection. Here, we show that […]

Published June 2022 in Genetics in Medicine, in collaboration with Charité Universitätsmedizin Berlin. We identified a lipodystrophy phenotype with a typical facial appearance, corneal clouding, achalasia, progressive hearing loss, and variable severity. Although 3 individuals showed stunted growth, intellectual disability, and died within the first decade of life (A1, A2, and A3), 2 are adults […]

Published June 2022 in Science of the Total Environment, in collaboration with Duke University. Mixtures of per- and polyfluoroalkyl substances (PFAS) are often found in drinking water, and serum PFAS are detected in up to 99% of the population. However, very little is known about how exposure to mixtures of PFAS affects maternal and fetal […]